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Metabolism Diazepam is N-demethylated by CYP3A4 and 2C19 on the Lively metabolite N-desmethyldiazepam, which is hydroxylated by CYP3A4 to the Lively metabolite temazepam.Tolerance into the therapeutic outcome of diazepam may perhaps create; nonetheless, tiny tolerance develops to the amnestic reactions along with other cognitive impairments caused